Methods of Administration....

There are a number of methods to consume molecular hydrogen gas (H2), including inhalation of H2, injection of H2-rich saline, dropping H2-rich saline into eyes, taking a bath in H2-rich water, increasing H2 production by intestinal bacteria, topical application, oral ingestion of hydrogen producing tablets, and simply drinking H2-rich water.

Which method is best....

Each one of these methods has a therapeutic effect. Although drinking H2-rich water doesn’t provide as many hydrogen molecules to the body as other methods, it is likely the easiest and a very effective approach. In fact, in one study using a rat model of Parkinson’s disease, it was seen that drinking H2-rich water, but not inhaling 2% H2 gas or increasing intestinal H2 production via lactulose administration, was effective.


Perhaps this is because inhaling H2 gas and H2 gas production via the bacteria gives a continuous exposure of H2 (allowing homeostasis to be achieved), but drinking H2 water gives an intermittent exposure. Indeed this same study showed that intermittent inhalation of 2% H2 was somewhat effective. Another reason that drinking H2 water is important is because it allows gastric induction of ghrelin, which is mediated via activation of beta 1 adrenergic receptors. The consensus is that not only is drinking H2-rich water the easiest, it is often the most effective.

Methods to produce H2 rich water......

There are a number of ways to produce H2 water, including electrolysis (e.g. water ionizers, or hydrogen-specific devices), reaction of water with alkali-earth metals (e.g. elemental magnesium), or simply bubbling H2 gas into water.

Molecular Hydrogen Founder: Tyler LeBaron

Tyler LeBaron talks about Molecular Hydrogen and Autism.


Tyler LeBaron, Originally published: September 20, 2015

Dr.S.Ohta on Hydrogen Water...PLEASE pause and read subtitles......the information given here is EXTREMELY IMPORTANT!


Hype has reference to the placebo effect, which as discussed can be extremely powerful. The marketing hype and expected or non-expected benefits from drinking hydrogen-rich water can in and of themselves offer some significant health benefits. Read the placebo effect article for more information.



It is well known that most people simply don’t drink enough water. Many people are even chronically dehydrated. There are many studies, and case reports where people have been treated or their health significantly improved by simply drinking more water. In fact, dehydration of the elderly is often a primary cause for their hospitalization. Often, when people start drinking hydrogen water (or alkaline ionized water), they drink more water and thus are no longer dehydrated. Since the importance of drinking more water is often stressed, this assures that they are properly hydrated, giving them the benefits which accompany proper hydration.



Often, when people learn about hydrogen water, they are educated on health in general. They often stop drinking sugary drinks and consuming excess empty calories. Sometimes, sales agents require prospects to stop drinking any “unhealthy” beverages while trying the water. This is often easy for them because of the higher amount of water they are asked to drink. During these “trial periods”, people begin to alter not only their diet, but also improve on their exercise and lifestyle habits. All of these changes also directly provide additional health benefits.



It is assumed or hoped that the primary reason for the health benefits are derived from the molecular hydrogen in the water. It is the hydrogen in the water that provides the benefits in the water above and beyond just drinking adequate amounts of good clean drinking water. Hundreds of scientific studies have shown hydrogen to have therapeutic potential in many human and animal disease models.


In short, all four of these H’s are important and can contribute to the benefits of drinking hydrogen water. Importantly, they are not mutually exclusive. While you might not drink any additional water (Hydration) or make any lifestyle changes (Health), you are still susceptible to the placebo effect (Hype) and hopefully will also benefit from the Hydrogen. Sometimes it may be all of them except the hydrogen, because the hydrogen may have already dissipated out or may have never been fully dissolved in the water.

Reference Source: Tyler LaBaron Sept.20, 2015

Hydrogen Water Helps Parkinson’s Disease Clinical Studies

Molecular Hydrogen helps anti-ageing.

Molecular Hydrogen and Gut Health

The effect of Hydrogen Water on our Colon

​Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.

Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L646-56. doi: 10.1152/ajplung.00164.2012. Epub 2013 Mar 8.

Kawamura T1, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y, Kensler TW, Nakao A.

Author information

Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.


Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Hydrogen can be administered as a therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and induced heme oxygenase (HO)-1. To determine whether hydrogen could reduce hyperoxic lung injury and investigate the underlying mechanisms, we randomly assigned rats to four experimental groups and administered the following gas mixtures for 60 h: 98% oxygen (hyperoxia), 2% nitrogen; 98% oxygen (hyperoxia), 2% hydrogen; 98% balanced air (normoxia), 2% nitrogen; and 98% balanced air (normoxia), 2% hydrogen. We examined lung function by blood gas analysis, extent of lung injury, and expression of HO-1. We also investigated the role of NF-E2-related factor (Nrf) 2, which regulates HO-1 expression, by examining the expression of Nrf2-dependent genes and the ability of hydrogen to reduce hyperoxic lung injury in Nrf2-deficient mice. Hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression. Hydrogen did not mitigate hyperoxic lung injury or induce HO-1 in Nrf2-deficient mice. These findings indicate that hydrogen gas can ameliorate hyperoxic lung injury through induction of Nrf2-dependent genes, such as HO-1. The findings suggest a potentially novel and applicable solution to hyperoxic lung injury and provide new insight into the molecular mechanisms and actions of hydrogen.


Hyperbaric hydrogen therapy: a possible treatment for cancer.

Science. 1975 Oct 10;190(4210):152-4.

Dole M, Wilson FR, Fife WP.


Hairless albino mice with squamous cell carcinoma were exposed to a mixture of 2.5 percent oxygen and 97.5 percent hydrogen at a total pressure of 8 atmospheres for periods up to 2 weeks in order to see if a free radical decay catalyzer, such as hydrogen, would cause a regression of the skin tumors. Marked aggression of the tumors was found, leading to the possibility that hyperbaric hydrogen therapy might also prove to be of significance in the treatment of other types of cancer.

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